October 12, 2008
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Medical Ghosties and Ghoulies
“Crystal water turns to dark
Where ere it’s presence leaves it’s mark
And boiling currents pound like drums
When something wicked this way comes…A presence dark invades the fair
And gives the horses ample scare
Chaos rains and panic fills the air
When something wicked this way comes…Ill winds mark it’s fearsome flight,
And autumn branches creak with fright.
The landscape turns to ashen crumbs,
When something wicked this way comes… “The above is an excerpt from Ray Bradbury’s poem, Something Wicked this way Comes, and one of my favorite Halloween type poems. I have to say, Halloween is one of my favorite holidays because it is one of the few times a year that even grown ups are allowed to play lets pretend, and scare ourselves silly.
And part of those horror tales we used to tell ourselves as kids involved vampires and werewolves and zombies, the monsters of lore. But did they really exist? And if not, who came up with the idea? Well, too much studying for boards has enabled me to dig up this fascinating little tidbit about a disease called Porphyria Cutanea Tarda
Porphyrins are used in the creation of the 4 porphyrin rings in your hemoglobin (the part of the red blood cell that holds the iron). Certain diseases, among them PCT affect these rings. PCT primarily causes skin problems such as blisters that appear on sun exposed areas of the body such as the hands and face. Even after minor trauma like a cut, the skin in these area can peel or blister.
In addition, people with PCT may also have darkening and thickening of the skin, as well as increased hair growth
Hmm…is this starting to resemble any monsters of old yet?
Thats right, The very first werewolves of european folklore may have been none other than folks with a genetic condition. Of course, what were werewolves without vampires? In another extremely rare form of the disorder called congenital erythopoietic porphyria, the teeth can be stained a reddish brown due to the buildup of pigments
The symptoms of PCT can be alleviated by avoiding sunlight, since exposure to such light severely aggravates the symptoms of the porphyrias.
Along with avoidance of sunlight, since many of the porphyrias involve a deficiency of red blood cells, affected patients appear very pale and may require repeated blood transfusions.Of course people in the old country didnt have the benefit of modern medical science (or google image search) and given that these are fairly rare conditions it is no wonder that the townsfolk believed monsters lives among them. And that is without even getting into the parallels between epilepsy and demon possesion, or zombies and prion diseases and voodo. But all things considered, the human body is pretty darn amazing, dont you think?
Until the next study break folks…
-Almost Dr J.
“Flowers bloom as black as night
Removing color from your sight
Nightmarish vines block your way
Thorns reach out to catch their preyAnd by the pricking of your thumbs
Realize that their poison numbs
From frightful blooms, rank odors seep
Bats & beasties fly & creep‘Cross this evil land, ill winds blow
Despite the darkness, mushrooms glow
All will rot & decompose
For something wicked this way grows…“
Comments (16)
@Rveblade - Living with this condition has two sides to it, at one end it is awesome to be compared to vampires and werewolves, which I loved them already. Then there is the other end which is filled with pain, suffering, having to deal with business only during the day, people calling me a hypochondriac even if they have witnessed the symptoms, kids in school picking at me for being different, and people just in general not understanding anything about the disorder. My husband is sometimes embarassed by my arm hair so it cover up so it’s not visible
I live with the fear of sunlight and the pain I go through when I go in the sun, which includes rashes across my face and shoulders and down my back, I lose control of some muscles and experience siezure-like mental disturbances where I lose consciousness after a tingling sensation in my face. Any sun contact can be compared to sticking my skin against a frying pan and splashing hot tobasco sauce on the burn and blisters, my body reacts and grows more and more hair to protect itself the more I have sunlight exposure, but being female it doesn’t look as bad as on a male subject. I suffer mild to severe psychotic episodes where I sometimes feel like killing someone, so I retreat to solitude and do activities that release my tensions.
As far as family members, my mother has very mild symptoms but still exhibits the same variation of the disorder as me, my sister is allergic to bananas and my family cannot use sulfite drugs, we are also very sensitive even to an allergy level of sensitivity to anything in the garlic and onion family, the allicin reacts with a porphyric’s brain, thus the vampire not liking garlic myth can be cleared up =) My older sister thinks I’m a hypochondriac so I don’t talk to her about most of this.
I am on neurontin for the neuropathy developed from the disorder, neurontin also affects the entire neural system so the problems associated with that are dampened and are more tolerable. For the buildup of porphyrins there’s a formula they pump through the bloodstream that bonds to porphyrins and removes them from the body through the waste. I am not on this treatment, but I would love to go to a porphyria specialist and have it done so I could reduce my physical problems, maybe even some chinese treatments or detox. If you want to know more from the perspective of someone with it, please ask specific questions and I would be happy to answer anything that I am able to answer.
~Lycantis
@Lycantis - thank you for your kind comments lycantis. I just wrote about something I found fascinating and wanted to share with others. What is it like to live with this condition? does anyone else in your family have it? do you undergo any treatments I have neglected to mention above? From a medical standpoint, i would love to know anything you are willing to share. thanks again for stopping by
I have hereditary coproporphyria, I am covered head to toe in thick hair. I do have a fascination with werewolves and vampires, and thus I wrote a novel based on these fascinating beasts of ancient lore. Underworld looked the best when it comes to werewolf depictions. This is a very good report, it is what I suffer with every time I go in the light, so I am nocturnal for the most part, too bad daywalkers won’t realize some people can’t be in sunlight or I could avoid going to the clinics in broad daylight and then at random points suddenly developing rashes and abdominal siezures and pain. You did a great paper here.
~Lycantis
cool;aid yo .. I was searching cutanea porphyria tarda and stumbled into your blog
2nd to the last pic – that dude has a big head..
@Rveblade - good luck
Good luck with the boards! When do you take them?
some interesting stuff alright.
Wow! Thank you for enlightening me.
@orient03 - optho…I am interviewing at NYMC in december
@NYMC. Are you applying for surgery?
@Lemunia - hey frank, everyone’s doing great at the moment…how about you and your family? everyone well?
Oo… graphic.
Thanks
But I’m over the AMCAS (that was a year ago), and don’t usually update xanga (blogspot)… Just starting Gross Block IV (head/neck) now – I’m sure it’ll be a joy. Hope 4th year is going well.
Hey Josh!
Nice job promoting Booby cancer awareness!
I hope your mom and her home’re okay and out of the way of the flameage goin on now.
-Frank
Whoa….crazy stuff.
Fascinating stuff, Dr. J.